
職務:教授、博導,教育部新世紀人才
院系:流行病與衛生統計學系
地址:湖北省武漢市航空路13号 430030
電話:
郵箱:miaoxp@hust.edu.cn
缪小平,流行病學教授,擔任中國抗癌協會病因專委會副主任委員、中國醫師協會公共衛生醫師分會總幹事和中華醫學會公共衛生分會委員。獲中國腫瘤青年科學家獎和湖北省自然科學二等獎(排名第一)。曾主持國家自然科學基金優秀青年基金、中組部青年拔尖人才支持計劃等人才項目。主要從事腫瘤分子流行病學研究:發現了中國人群結直腸癌、食管癌和胰腺癌的高作用效能易感基因,為個體化預防提供了重要線索,結果分别發表在Cancer Res、Nat Genet和Nat Commun;闡明了結直腸癌非編碼區易感位點的生物學機制,為充分認識人類基因組“荒漠區”提供了人群證據;揭示了影響結直腸癌易感性的基因-環境和基因-基因交互作用,為構建腫瘤風險預測模型提供了依據。近5年作為通訊作者發表SCI論文31篇,其中IF>10的8篇,另有6篇入選ESI高被引論文,在web of science數據庫中的H指數為46。
代表性論文
(詳見ResearchID: http://www.researcherid.com/rid/C-4336-2011;
Google scholar: http://scholar.google.co.uk/citations?user=biJN_2kAAAAJ&hl=en )
1. Tian J, Wang Z, Mei S, Yang N, Yang Y, Ke J, Zhu Y, Gong Y, Zou D, Peng X, Wang X, Wan H, Zhong R, Chang J, Gong J, Han L, Miao X. CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer. Nucleic Acids Res. 2019;47(D1):D909-D916.
2. Yang Y, Peng X, Ying P, Tian J, Li J, Ke J, Zhu Y, Gong Y, Zou D, Yang N, Wang X, Mei S, Zhong R, Gong J, Chang J, Miao X. AWESOME: a database of SNPs that affect protein post-translational modification. Nucleic Acids Res. 2019;47(D1):D874-D880.
3. Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C*, Miao X*, Lin D. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018; 50(3):338-343.
4. Gong J, Tian J, Lou J, Wang X, Ke J, Li J, Yang Y, Gong Y, Zhu Y, Zou D, Peng X, Yang N, Mei S, Zhong R, Chang J, Miao X. A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267. Ann Oncol. 2018;29(3):632-639.
5. Chang J, Tian J, Zhu Y, Zhong R, Zhai K, Li J, Ke J, Han Q, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Yang M, Wang L, Wu C*, Lin D*, Miao X*.Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun. 2018;9(1):3688.
6. Chang J, Tian J, Yang Y, Zhong R, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Zhu Y, Zou D, Peng X, Huang K, Miao X. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res. 2018;78(17):5164-5172.
7. Li J, Chang J, Tian J, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Mei S, Wang X, Cheng L, Hu W, Gong J, Zhong R, Miao X. A rare variant P507L in TPP1 interrupts TPP1-TIN2 interaction, influences telomere length, and confers colorectal cancer risk in Chinese population. Cancer Epidemiol Biomarkers Prev. 2018;27(9):1029-1035.
8. Zou D, Lou J, Ke J, Mei S, Li J, Gong Y, Yang Y, Zhu Y, Tian J, Chang J, Zhong R, Gong J, Miao X. Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. Eur J Cancer. 2018;93:1-9.
9. Lou J, Gong J, Ke J, Tian J, Zhang Y, Li J, Yang Y, Zhu Y, Gong Y, Li L, Chang J, Zhong R, Miao X. A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations. Carcinogenesis. 2017;38(2):177-183.
10. Gong J, Tian J, Lou J, Ke J, Li L, Li J, Yang Y, Gong Y, Zhu Y, Zhang Y, Zhong R, Chang J, Miao X. A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis. 2016;37(5):443-451.