劉莉

來源：時間：2021-10-15 點擊量：次

職務：8858ccl8利网址教授，博士生導師

院系：流行病與衛生統計學系

地址：湖北省武漢市航空路13号 430030

電話：86-27-83693763

2007年畢業于8858ccl8利网址預防醫學專業，2012年在8858ccl8利网址同濟醫學院獲醫學博士學位。2016.1-2017.12在哈佛大學醫學院Dana-Farber Cancer Institute及哈佛大學8858ccl8利官网做博士後研究，具有大隊列數據分析及管理經驗。主要研究方向：營養流行病學、腫瘤流行病學，重點關注飲食、菌群、免疫在結直腸癌發生發展中的作用。承擔了國家自然科學基金、湖北省衛生健康委預防轉項-重點項目、中國科協、教育部博士點課題等多項項目，作為課題骨幹參與了國家重點研發項目、湖北省技術創新專項重大項目、國家自然基金重點項目等。已發表SCI論文近30篇，總IF超過200分，其中以第一作者或通訊作者在JAMA，Gastroenterology，Gut，Br J Sports Med，J Am Soc Nephrol，Clin Gastroenterol Hepatol，Eur J Epidemiol，Environ Int，Cancer等雜志上發表論文。獲得湖北省科技進步二等獎（第二完成人），中國抗癌協會科技獎二等獎（第三完成人）。現擔任Clinical Cancer Research，EbioMedicine等雜志的審稿人。

主要承擔和參與的科研項目

2014-2016 全基因組表達相關拷貝數變異在結直腸癌發生發展中的作用及機制研究，國家自然基金青年基金 (81302491)

2014-2016 全基因組表達相關拷貝數變異在結直腸癌易感性中的作用，教育部博士點課題

2013-2014 端粒酶基因多态性、端粒長度在膽囊癌易感性中的作用，校自助創新課題(2013QN001)

2010-2015中國農村地區傳染病整合監測系統：為資源匮乏地區疾病流行的早期發現收集證據，歐盟第七框架計劃項目 (241900)

2015-2019線粒體動力學改變在氟神經毒性中的作用及白藜蘆醇幹預效果研究，國家自然基金重點項目 (81430076)

2014-2017遺傳易感性和早期生活方式的交互作用在嬰兒肥胖發生中的作用，國家自然基金面上項目 (81373017)

2012-2015 Wnt信号通路及其關鍵靶基因與結直腸癌遺傳易感性的關聯研究，國家自然基金面上項目 (81172752)

2012-2014 妊娠期骨骼鉛動員的MTFHR、VDR基因多态性及相關因素研究，國家自然基金青年基金 (81102185)

2012-2014 鉀離子信号網絡基因遺傳變異與注意缺陷多動障礙易感性研究，國家自然基金青年基金 (81101016)

代表性論著

1. Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, Huang J, He N, Yu H, Lin X, Wei S, Wu T. Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020 Apr 10;323(19):1-9. (Co-first author)

2. Xiong F, Tang H, Liu L, Tu C, Tian J, Lei C, Liu J, Dong J, Chen W, Wang X, Luo D, Shi M, Miao X and Zhang C. Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China. J Am Soc Nephrol

. 2020 Jul;31(7):1387-1397. (Co-first author)

3. Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 Dec;153(6):1517-1530.e14.

4. Yang W, Liu L, Masugi Y, Qian ZR, Nishihara R, Keum N, Wu K, Smith-Warner S, Ma Y, Nowak JA, Momen-Heravi F, Zhang L, Bowden M, Morikawa T, Silva AD, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Ng K, Giovannucci E, Ogino S, Zhang X. Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 Aug;67(8):1475-1483. (co-first author)

5. Li T, Wei S, Shi Y, Pang S, Qin Q, Yin J, Deng Y, Chen Q, Wei S, Nie S, Liu L. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016 Mar;50(6):339-45.

6. Liu L, Shi Y, Li T, Qin Q, Yin J, Pang S, Nie S, Wei S. Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies. Br J Sports Med. 2016 Mar;50(6):372-8.

7. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1622-1631.e3.

8. Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018 Sep;118:116-124. (Co-corresponding author)

9. Hamada T, Liu L, Nowak JA, Mima K, Cao Y, Ng K, Twombly TS, Song M, Jung S, Dou R, Masugi Y, Kosumi K, Shi Y, da Silva A, Gu M, Li W, Keum N, Wu K, Nosho K, Inamura K, Meyerhardt JA, Nevo D, Wang M, Giannakis M, Chan AT, Giovannucci EL, Fuchs CS, Nishihara R, Zhang Z, Ogino S. Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 Sep 12;103:98-107. (co-first author)

10. Kosumi K, Hamada T, Zhang S, Liu L, da Silva A, Koh H, Twombly TS, Mima K, Morikawa T, Song M, Nowak JA, Nishihara R, Saltz LB, Niedzwiecki D, Ou FS, Zemla T, Mayer RJ, Baba H, Ng K, Giannakis M, Zhang X, Wu K, Giovannucci EL, Chan AT, Fuchs CS, Meyerhardt JA, Ogino S. Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 Apr;111:82-93. (co-first author)

11. Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S.Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 Apr;33(4):381-392.

12. Liu L, Chen H, Li Y, Li H, Li J, Wang Y, Yao S, Qin C, Tong S, Yuan X, Luo X, Miao X, Pan A, Liu Z, Cheng L. Temporal Profiles of Antibody Responses, Cytokines, and Survival of COVID-19 Patients: A Retrospective Cohort in Wuhan, China. Engineering (Beijing). 2021 May 18. doi: 10.1016/j.eng.2021.04.015.

13. Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, Xu Y, Wu J, Duan S, Rui R, Wu T, Nie S, Miao X, Lin D. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011 Jan;125(2):479-87.

14. Yu X, Xia L, Zhang S, Zhou G, Li Y, Liu H, Hou C, Zhao Q, Dong L, Cui Y, Zeng Q, Wang A, Liu L. Fluoride exposure and children's intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study. Environ Int. 2021 Jun 4;155:106681. doi: 10.1016/j.envint.2021.106681.

15. Wang K, Yu X, Jiang H, Huang J, Wang H, Jiang H, Wei S, Liu L. Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese. Mol Carcinog. 2019 Jul;58(7):1324-1333.

16. Liu L, Wu J, Zhong R, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S, Lin D, Miao X. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013 Dec;52(12):923-31.

17. Pang S, Zhou Z, Yu X, Wei S, Chen Q, Nie S, Liang X, Liu L.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma: A Retrospective Cohort Study. Int J Surg. 2017 Jun;42:170-177.

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