學曆：

醫學學士：1983年，原同濟醫科大學8858ccl8利官网
醫學碩士：2001年，8858ccl8利网址同濟醫學院8858ccl8利官网
醫學博士：2003年，Ulm University, Germany

工作經曆：

1983-1987 中山醫科大學8858ccl8利官网衛生統計學教研室

1987-1992 原同濟醫科大學8858ccl8利官网環境衛生學教研室

1992-1994 訪問學者，Center for Advanced Biotechnology and Medicine, UMDNJ-Robert Wood Johnson Medical School, NJ, USA

1995-1999 原同濟醫科大學8858ccl8利官网環境衛生學教研室

1999-1999 訪問學者，Charité Campus Virchow-Klinikum,Universitätsmedizin Berlin, Humbold University of D-Berlin, Berlin,Germany

2000-2001 8858ccl8利网址同濟醫學院8858ccl8利官网環境衛生學教研室

2002-2003 學生學者，Charité Campus Virchow-Klinikum,Universitätsmedizin Berlin, Humbold University of D-Berlin, Berlin,Germany

2004-2005 8858ccl8利网址同濟醫學院8858ccl8利官网環境衛生學教研室

2005-present 8858ccl8利网址同濟醫學院8858ccl8利官网勞動衛生與環境衛生學系

在研項目：

1. 國家自然科學基金面上項目： Sirtuins參與TCEP緻細胞損傷的線粒體調控機制研究.（項目編号：81273023, 2013-2016.12）。

2. 國家自然科學基金面上項目：SEC14L3激活PI3K/Akt信号通路調控BaP與DEHP緻細胞損傷的機制研究. （項目編号：81472947，2015-2018）”

3. 環保公益項性行業科研專項“典型區域細顆粒物污染特征與人群健康風險預警指标體系研究”課題（項目編号：201409081）

研究領域

• 環境重要污染物（顆粒物、多環芳烴、增塑劑等）暴露水平及其人群健康危害研究

• 環境重要有機污染物（B[a]P、DEHP、MEHP、TCEP)的分子毒性機制研究

發表論文：

1. Zhang W, Zhang Y, Xu T, Wang Z, Wang J, Xiong W, Lu WH, Zheng H, Yuan J*. Involvements of ROS-mediated mitochondrial dysfunction and SIRT3 down-regulation in tris(2-chloroethyl)phosphate-induced cell cycle arrest. Toxicol Res. 2016, 5, 461-470

2. Zhou Y†, Sun H†, Xie J, Song Y, Liu Y, Huang X, Zhou T, Rong Y, Wu T, Yuan J*, Chen W*. Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Altered Lung Function in Wuhan, China. Am J Respir Crit Care Med. 2015 Dec 4. [Epub ahead of print]

3. Hou J†, Sun H†, Xiao L, Zhou Y, Yin WJ, Xu T, Cheng J, Chen W*, Yuan J*. Combined effect of urinary monohydroxylated polycyclic aromatic hydrocarbons and impaired lung function increased risk of diabetes. Envrion Res (Accepted)

4. Hou F†, Huang X†, Liu C†, Sun H, Zhou T, Song Y, Rong Y, Zhu B, Chen W, Wang J, Wang J, He M, Miao X, Hoffmann B, Wu T, Chen W*, Yuan J*. Housing characteristics in relation to exhaled nitric oxide in China. Am J Health Behav. 2015, 39(1):88-98

5. Hou J†, Liu C†, Yao P†, Chen W, He M, Wang Y, Liang Y, Miao X, Wei S, Xu T, Fang W, Zhu J, Li X, Hu FB, Wu T, Yang H*, Yuan J*. Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults. PloS One. 2015;10(6):e0129677. doi: 10.1371/journal.pone.0129677.

6. Zhang W, Zhang Y, Wang Z, Xu T, Huang C, Yin W, Wang J, Xiong W, Lu W, Zheng H, Yuan J*. Tris-(2-chloroethyl)-phosphate induced cell growth arrest via attenuation of SIRT1-independent PI3K/Akt/mTOR pathway. J Appl Toxicol. 2015, doi: 10.1002/jat.3223

7. Yang G, Zhang W, Qin Q, Wang J, Zheng H, Xiong W, Yuan J*. Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environ Toxicol. 2015, 30(10):1178-91. doi: 10.1002/tox.21990

8. Fang Ye, Xiaoyi Li, Lili Li, Ling Lv, Jing Yuan*, Jun Chen*. The role of Nrf2 in protection against Pb-induced oxidative stress and apoptosis in SH-SY5Y cells. Food Chem Toxicol, 2015, 86:191-201. doi: 10.1016/j.fct.2015.10.009.

9. Feng Y†, Huang X, Sun H, Liu C , Zhang B, Zhang Z, Sharma Tengur V, Chen W, Wu T, Yuan J*, Zhang X*. Framingham risk score modifies the effect of PM10 on heart rate variability. Sci Total Environ. 2015, 523:146-51. doi: 10.1016/j.scitotenv.2015.04.009.

10. Yang G†, Zhang W†, Qin Q, Wang J, Zheng H, Xiong W, Yuan J*. MEHP induced apoptosis in p53-silenced L02 cells via activations of mitochondrial pathway and death receptor pathways. Environ Toxicol. 2015, 30(10):1178-91. doi: 10.1002/tox.21990.

11. Liu C, Yang Y, He M, Yao P, Chen W, Liang Y, Wang Y, Fang W, Zhu J, Li X, Yang H, Yuan J*, Hu FB, Wu T. Passive smoke exposure was related to mean platelet volume in Never-smokers. Am J Health Behav 2014, 38(4):519-528

12. Song Y, Hou J, Huang X, Zhang X, Tan A, Rong Y, Sun H, Zhou Y, Cui X, Yang Y, Guo Y, Zhang Z, Luo X, Zhang B, Hou F, He X, Xie J, Wu T, Chen W*, Yuan J. The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort. BMC Public Health. 2014, 14:994. doi: 10.1186/1471-2458-14-994.

13. Jiang Y†, Chen X†, Yang G, Wang Q, Wang J, Xiong W, Yuan J*. BaP-induced DNA damage initiated p53-independent necroptosis via the mitochondrial pathway involving Bax and Bcl-2. Hum Exp Toxicol. 2013, 32(12):1245-57. doi: 10.1177/0960327113488613

14. Chen X†, Qin Q†, Zhang W, Zhang Y, Zheng H, Liu C, Yang Y, Xiong W, Yuan J*. Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation. Food Chem Toxicol. 2013, 59:325-33. doi: 10.1016/j.fct.2013.06.016.

15. Chen X, Wang J, Qin Q, Jiang Y, Yang G, Rao K, Wang Q, Xiong W, Yuan J*. Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells. Environ Toxicol Pharmacol. 2012, 33(3):421-30. doi: 10.1016/j.etap.2012.02.001.

16. Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, Yuan J*. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol. 2012, 50(7):2424-31. doi: 10.1016/j.fct.2012.04.023.

編寫教材：

1. 衛生部“十二五”規劃教材、全國高等醫藥教材建設研究會“十二五”規劃教材、全國高等學校教材《預防醫學》（供本科護理學類專業用）第3版。2012，北京：人民衛生出版社.（副主編）

2. 國家衛生和計劃生育委員會“十二五”規劃教材、全國高等醫藥教材建設研究會“十二五”規劃教材、全國高等學校教材，供8年制及7年制（“5+3”一體化）臨床醫學等專業用《預防醫學》（第三版）.人民衛生出版社.（編委）

3. 國家醫學電子書包《衛生學》.人民軍醫出版社.（副主編）

4. 全國高等學校醫學研究生規劃教材《分子毒理學》.人民衛生出版社.（主編）