個人簡介

8858ccl8利网址8858ccl8利官网副教授，博士生導師，湖北省青年拔尖人才。2013年獲8858ccl8利网址流行病與衛生統計學博士學位；2016年被聘為8858ccl8利网址8858ccl8利官网副教授；2019年9月至2021年3月赴美國哈佛大學醫學院附屬布列根和婦女醫院開展博士後研究工作。主持8858ccl8利网址教學改革項目，國家自然科學基金面上項目、青年項目、中國博士後科學基金面上一等資助和特别資助等項目，以通訊作者和第一作者（含共同）在Nature Genetics、Cancer Discovery、Nat Rev Clin Oncol、Oncogene和Clin Gastroenterol Hepatol等雜志發表SCI論文43篇。獲湖北省自然科學獎二等獎（排名第三），8858ccl8利网址教學競賽二等獎和湖北省優秀博士學位論文等獎項。主要從事環境、基因與消化系統腫瘤發病風險的研究。應用多中心病例-對照研究和前瞻性隊列研究，對影響消化系統腫瘤的遺傳和環境病因進行了較深入的探讨，并系統整合遺傳資源和環境暴露數據，試圖構建基因-環境交互作用模型和腫瘤風險預測模型，為腫瘤高風險個體的篩查和個體化防治提供重要科學依據。現擔任American Journal of Gastroenterology, Cancers, Molecular Carcinogenesis等雜志的審稿人。

研究方向：腫瘤流行病學；健康大數據的挖掘

主要負責的科研項目

1. 中國人群肝癌分子流行學研究，湖北省青年拔尖人才支持項目，時間：2022 -2024，經費：60萬元

2. LncRNAs調控型遺傳變異與中國人群肝癌易感性及機制研究，國家自然科學基金（面上項目），時間：2019 -2022，經費：58萬元

3. 基于大數據的腫瘤風險預測模型在前瞻性隊列人群中的驗證研究， 國家重點研發計劃“重大慢性非傳染性疾病防控研究”專項子課題，時間：2016 -2020，分撥經費：10萬元

4. FOXA1先鋒轉錄因子靶基因結合區遺傳變異與乳腺癌易感性的關系及機制研究，國家自然科學基金（青年項目），時間：2015 -2017，經費：23萬元

5. 叉頭框A蛋白靶基因結合區遺傳變異與肝癌易感性研究，中國博士後科學基金會，時間：2013-2015，經費：8萬元

6. 乙肝病毒受體分子遺傳多态與HBV易感性的研究，經費來源：中國博士後科學基金會，時間：2014-2016，經費：15萬元

7. TGF-β信号通路關鍵基因低頻遺傳變異與結直腸癌易感性研究，經費來源：8858ccl8利网址自主創新研究基金，時間：2015-2016，經費：5萬元

代表性論著

(^†co-first author, *Corresponding author)

1. Gurjao C^†, Zhong R^†, Haruki K^†, Li Y, Spurr, L, Spurr H, et al. Discovery and features of an alkylating signature in colorectal cancer. Cancer Discovery. 2021; 11(10):2446-2455. (^†co-first author)

2. Chang J^†, Zhong R^†, Tian J^†, Li J^†, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C*, Miao X*, Lin D. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018; 50(3):338-343,. (^†co-first author)

3. Zhong R, Tian J, Fu M, Ma S, Liu L, Li J et al. LINC01149 variant modulates MICA expression that facilitates hepatitis B virus spontaneous recovery but increases hepatocellular carcinoma risk. Oncogene. 2020; 39(9):1944-1956.

4. Wang H^†, Yang B^†, Cai X, Cheng X, Shen N, Liu L, Li J, Wang Y, He H, Ying P, Li B, Lu Z, Yang N, Wang X, Zhang F, Li Y, Wang W, Ning C, Zhu Y, Chang J, Miao X, Tian J*, Zhong R*. Hepatocellular carcinoma risk variant modulates lncRNA HLA-DQB1-AS1 expression via a long-range enhancer-promoter interaction. Carcinogenesis. 2021;42(11):1347-1356. (*Corresponding author)

5. He H, Deng Y, Wan H, Shen N, Li J, Zeng Q, Chang J, Lu Q, Miao X, Tian J*, Zhong R*. Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk. Chemosphere. 2022;286(Pt 3):131880. (*Corresponding author)

6. Jin W, Jiang G, Yang Y, Yang J, Yang W, Wang D, Niu X, Zhong R*, Zhang Z*, Gong J*. Animal-eRNAdb: a comprehensive animal enhancer RNA database. Nucleic acids research. 2022;50(D1):D46-D53. (*Corresponding author)

7. Li B, Cheng X, Zhu Y, Wan H, Lu Z, Cai Y, Li W, Yi P, Liu L, Chang J, Miao X, Tian J*, Zhong R*. FOXA1 of regulatory variant associated with risk of breast cancer through allele-specific enhancer in the Chinese population. Breast cancer. 2022;29(2): 247-259.

8. Zhong R^†, He H^†, Jin M^†, Lu Z, Deng Y, Liu C, Shen N, Li J, Wang H, Ying P, Li B, Zeng Q, Lu Q, Cheng L, Zhu Y, Miao X, Tian J. Genome-wide gene-bisphenol A, F and triclosan interaction analyses on urinary oxidative stress markers. The Science of the total environment. 2022;807(Pt 1):150753. (^†co-first author)

9. Akimoto N^†, Ugai T^†, Zhong R^†, Hamada T, Fujiyoshi K, Giannakis M, Wu K, et al. Rising incidence of early-onset colorectal cancer - a call to action. Nat Rev Clin Oncol. 2021; 18(4):230-243. (^†co-first author)

10. Deng Y, He H, Wan H, Shen N, Li J, Zhang S, Zeng Q, Chang J, Lu Q, Zhong R*, Miao X. Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers. Environ Pollut. 2021; 287:117630. (*Corresponding author)

11. Ugai T^†, Haruki K^†, Vayrynen JP^†, Zhong R^†, Borowsky J, Fujiyoshi K, Lau MC, et al. Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response. JNCI Cancer Spectr. 2020; 4(6):pkaa068,. (^†co-first author)

12. Akimoto N^†, Zhao M^†, Ugai T^†, Zhong R^†, Hamada T, Fujiyoshi K, Giannakis M, Wu K, et al. Tumor long interspersed nucleotide element-1 (LINE-1) hypomethylation in relation to age at diagnosis of colorectal cancer. Cancers. 2021; 13(9):2016. (^†co-first author)

13. Deng Y, Wan H, Tian J, Cheng X, Rao M, Li J, Zhang H, Zhang M, Cai Y, Lu Z,.Li Y, Niu S, Shen N, Chang J, Fang Z*, Zhong R*. CpG-methylation-based risk score predicts progression in colorectal cancer. Epigenomics. 2020; 12(7):605-615. (*Corresponding author)

14. Gong Y^†, Hu N^†, Ma L, Li W, Cheng X, Zhang Y, Zhu Y, Yang Y, Peng X, Zou D, Tian J, Yang L, Mei S, Wang X, Lo C. H., Chang J, Hou T, Zhang H, Xu B, Zhong R*, Yuan P*. ABTB2 Regulatory Variant as Predictor of Epirubicin-Based Neoadjuvant Chemotherapy in Luminal A Breast Cancer. Front Oncol. 2020; 10:571517. (*Corresponding author)

15. Shen N, Wang P, Li Y, Zhu Y, Gong Y, Zhong R*, Lu Y*, Cheng L*. Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus-related subjects. Mol Carcinog. 2020; 59(8):980-988. (*Corresponding author)

16. Cheng X, Wang Y, Tian J, Zhou L, Chen X, Guo H, Zeng J, Shen N, Li J, Ke J, Zhu Y, Gong J, Chang J, Liu L*, Zhong R*. SLC10A1 S267F variant influences susceptibility to HBV infection and reduces cholesterol level by impairing bile acid uptake. J Viral Hepat. 2019; 26(10):1178-1185. (*Corresponding author)

17. Zhu B, Zhu Y, Tian J, Shen N, Li J, Lou J, Ke J, Yang Y, Gong Y, Gong J, Chang J, Miao X*, Zhong R*. A functional variant rs1537373 in 9p21.3 region is associated with pancreatic cancer risk. Mol Carcinog. 2019; 58(5):760-766. (*Corresponding author)

18. Wang S, Xiang C, Mou L, Yang Y, Zhong R*, Wang L et al. Trans-acting nonsynonymous variant of FOXA1 predisposes to hepatocellular carcinoma through modulating FOXA1-ERalpha transcriptional program and may have undergone natural selection. Carcinogenesis.2020; 41(2):146-158. (*Corresponding author)

19. Shen N^†, Li L^†, Xu W, Tian J, Yang Y, Zhu Y, Gong Y, Ke J, Gong J, Chang J, Zhong R*, Miao X*. A missense variant in PTPN12 associated with the risk of colorectal cancer by modifying Ras/MEK/ERK signaling. Cancer Epidemiol.2019; 59: 109-114. (*Corresponding author)

20. Gong Y, Cheng X, Tian J, Li J, Zhu Y, Yang Y, Zou D,Peng X, Luo J, Zhao L, Mei S, Wang X, Yang L, Ke J, Gong J, Chang J, Wang Y*, Zhong R*. Integrative analysis identifies genetic variant modulating MICA expression and altering susceptibility to persistent HBV infection. Liver International. 2019; 39(10):1927-1936. (*Corresponding author)

21. Zhang Y^†, Yang B^†, Cheng X, Liu L, Zhu Y, Gong Y, Yang Y, Tian J, Peng X, Zou D, Yang L, Mei S, Wang X, Lou J, Ke J, Li J, Gong J, Chang J, Yuan P*, Zhong R*. Integrative functional genomics identifies regulatory genetic variant modulating RAB31expression and altering susceptibility to breast cancer. Mol Carcinog. 2018; 57(12): 1845-1854. (*Corresponding author)

22. Chang J^†, Tian J^†, Zhu Y^†, Zhong R^†, Zhai K, Li J, Ke J, Han Q, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Yang M, Wang L, Wu C*, Lin D*, Miao X*. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun. 2018; 9(1), 3688. (^†co-first author)

23. Chang J^†, Tian J^†, Yang Y^†, Zhong R^†, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Zhu Y, Zou D, Peng X, Huang K, Miao X*. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res. 2018; 78(17): 5164-5172. (^†co-first author)

24. Li J, Wang Y, Zhu Y, Gong Y, Yang Y, Tian J, Zhang Y, Zou D, Peng X, Ke J, Gong J, Zhong R*, Chang J*. Breast cancer risk-associated variants at 6q25.1 influence risk of hepatocellular carcinoma in a Chinese population. Carcinogenesis.2017; 38(4):447-454. (*Corresponding author)

25. Zhang Y, Li Y, Jiang S, Chen W, Lou J, Ke J, Li J, Zhu Y, Gong Y, Yang Y, Tian J, Peng X, Zou D, Gong J, Chang J, Miao X*, Zhong R*. A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population. Oncotarget. 2016; 7(49): 81691-81697. (*Corresponding author)

26. Chen X, Wu F, Liu Y, Lou J, Zhu B, Zou L, Chen W, Gong J, Wang Y*, Zhong R*. The contribution of serum hepatitis B virus load in the carcinogenesis and prognosis of hepatocellular carcinoma: evidence from two meta-analyses. Oncotarget. 2016; 7(31): 49299-49309. (*Corresponding author)

27. Chen X, Wang Y, Cheng K, Li J, Lou J, Ke J, Yang Y, Gong Y, Zhu Y, Wang L*, Zhong R*. Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance. Infection, Genetics and Evolution. 2016; 44: 495-500. (*Corresponding author)

28. Liu C^†, Zhong R^†, Lou J, Pan A, Tang Y, Chang J, Ke J, Li J, Yuan J, Wang Y, Chen W, Guo H, Wei S, Liang Y, Zhang X, He M, Hu FB, Wu T, Yao P, Miao X (2016) Nighttime sleep duration and risk of nonalcoholic fatty liver disease: the Dongfeng-Tongji prospective study. Annals of Medicine. 2016; 48(6): 468-476. (^†Co-first authors)

29. Zhong R, Liu L, Zou L, Sheng W, Zhu B, Xiang H, Chen W, Chen J, Rui R, Zheng X, Yin J, Duan S, Yang B, Sun J, Lou J, Xie D, Xu Y, Nie S*, Miao X*. Genetic variations in the TGFbeta signaling pathway, smoking and risk of colorectal cancer in a Chinese population. Carcinogenesis. 2013; 34(4), 936-942.

30. Zhong R, Chen X, Zhu B, Lou J, Li J, Shen N, Yang Y, Gong Y, Zhu Y, Yuan J, Xia X*, Miao X*. MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer. Sci Rep. 2015; 5:12202.

31. Zhu B, Zou L, Qi L, Zhong R*, Miao X*. Allium Vegetables and Garlic Supplements do Not Reduce Risk of Colorectal Cancer, Based on Meta-analysis of Prospective Studies. Clin Gastroenterol Hepatol. 2014; 12(12), 1991-2001. (*Corresponding author)

32. Zhong R, Liu L, Tian Y, Wang Y, Tian J, Zhu B, Chen W, Qian J, Zou L, Xiao M, Shen N, Yang H, Lou J, Qiu Q, Ke J, Lu X, Wang Z, Song W, Zhang T, Li H, Wang L*, Miao X*. Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis. Sci Rep. 2014; 4, 4147.

33. Zhong R, Liu L, Zou L, Zhu Y, Chen W, Zhu B, Shen N, Rui R, Long L, Ke J, Lu X, Zhang T, Zhang Y, Wang Z, Sun Y, Cheng L, Miao X*. Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. Mol Carcinog. 2013; 52 Suppl 1, E118-126.

34. Zhong R, Yang B, Tang H, Zou L, Song R, Zhu L*, Miao X*. Meta-analysis of the association between DCDC2 polymorphisms and risk of dyslexia. Mol Neurobiol. 2013; 47(1), 435-442.

35. Zhong R^†, Tian Y^†, Liu L^†, Qiu Q, Wang Y, Rui R, Yang B, Duan S Y, Shi J, Miao X*, Wang L*, Li H. HBV-related hepatocellular carcinoma susceptibility gene KIF1B is not associated with development of chronic hepatitis B. PLoS One. 2012; 7(2), e28839.

36. Chen W^†, Song H^†, Zhong R^†, Zhu B, Guo H, Lou J, Shen N, Li J, Chen X, Liu C, Ming J, Huang T*, Miao X*. Risk of GWAS-identified genetic variants for breast cancer in a Chinese population: A multiple interaction analysis. Breast Cancer Res Treat. 2013;142(3), 637-644. (^†Co-first authors)

37. Li J, Zou L, Chen W, Zhu B, Shen N, Ke J, Lou J, Song R, Zhong R*, Miao X*. Dietary mushroom intake may reduce the risk of breast cancer: evidence from a meta-analysis of observational studies. PLoS One. 2014;9: e93437. (*Corresponding author)

38. Zhang X^†, Zhong R^†, Zhang Z, Yuan J, Liu L, Wang Y, Kadlubar S, Feng F, Miao X*. Interaction of cyclooxygenase-2 promoter polymorphisms with helicobacter pylori infection and risk of gastric cancer. Mol Carcinog. 2011; 50(11), 876-883. (^†Co-first authors)

39. Zhang X^†, Zhong R^†, Liu L^†, Wang Y, Yuan J, Wang P, Sun C, Zhang Z, Song W, Miao X*. Smoking and cox-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in chinese population. PLoS One. 2011; 6(7), e21894. (^†Co-first authors)

40. Liu L^†, Zhong R^†, Zou L, Fu J, Zhu B, Chen W, Ye X, Gao Y, Yang Y, Christiani D. C. Chen S, Miao X. Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers. Cancer Epidemiol. 2014; 38(1):66-72. (^†Co-first authors)

41. Yang J^†, Duan S^†, Zhong R^†, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X*, Tang S*, Wang G*. Exome sequencing identified nrg3 as a novel susceptible gene of hirschsprung's disease in a Chinese population. Mol Neurobiol. 2013; 47(3), 957-966. (^†Co-first authors)

42. Liu L^†, Wu J^†, Zhong R^†, Wu C, Zou L, Yang B, Chen W, Zhu B, Duan S, Yu D, Tan W, Nie S*, Lin D*, Miao X*. Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Mol Carcinog. 2013; 52(12), 923-931. (^†Co-first authors)

43. Han W^†, Zhou Y^†, Zhong R^†, Wu C, Song R, Liu L, Zou L, Qiao Y, Zhai K, Chang J, Huang L, Lu X, Lou J, Yu D, Tan W, Zhang J, Wang H*, Miao X*. Functional polymorphisms in fas/fasl system increase the risk of neuroblastoma in chinese population. PLoS One. 2013; 8(8), e71656. (^†Co-first authors)

44. 陳偉, 張怡, 朱穎, 楊洋, 龔雅潔, 缪小平, 鐘榮. p53靶基因結合區遺傳變異與中國人群乳腺癌遺傳易感性的關聯研究. 中華流行病學雜志, 2016; 37(8): 1063-1068.（通訊作者）

45. 陳雪琴, 王英, 婁嬌, 楊洋, 龔雅潔, 朱穎, 向成, 鐘榮. MicroRNA-122結合區遺傳變異IL-1A rs3783553與慢性HBV感染的關聯研究. 8858ccl8利网址學報(醫學版) 2016:53-55+69.（通訊作者）