職務：教授，博士生導師

院系：衛生毒理學系

地址：湖北省武漢市航空路13号 430030

郵箱：yanhong@mails.tjmu.edu.cn

1992年本科畢業于同濟醫科大學環境醫學專業，1995和1998年同濟醫科大學衛生毒理學系研究生，獲醫學碩士和博士學位，2007.11-2008.12獲國家留學基金委資助作為訪問學者在美國University of Pennsylvania學習。自1998年7月畢業留校任教以來，一直從事衛生毒理學教學與科研工作，負責毒理學基礎和毒理學進展的課程教學，指導的本科畢業論文獲湖北省優秀學士學位論文獎。研究方向為外源化學物毒性作用及分子機制，主要關注環境化學物與神經退行性疾病的關系。主持多項國家自然科學基金面上項目、教育部留學回國啟動基金和中央高校自主創新研究基金等科研項目，并參加國家自然科學基金重點項目。主要社會兼職有湖北省毒理學會常務理事、中華預防醫學會衛生毒理學分會委員、中國毒理學會生化與分子毒理學專委會、神經毒理學專委會和毒理學教育專委會委員。參加編寫《食品毒理學》（副主編）、《毒理學基礎》雙語教材等。

近年發表主要論文（通訊作者）

1. Yan Dandan, Dai Lingling,Zhang Xing,Wang, Yiqi,Yan, Hong*，Subchronic Acrylamide Exposure Activates PERK-eIF2alpha Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus.ACS chemical neuroscience, 2022，13（9）：1370-1381

2. Dandan Yan, Na Wang, JianlingYao, XuWu, JingpingYuan , Yan, Hong*,Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells Neurochemical Research, 2022, 47：1037–1048

3. Yiqi Wang, Lian Duan, Xing Zhang,Yang Jiao, Ying Liu, Lingling Dai ,Hong Yan* ,Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum, Ecotoxicology and Environmental Safety 2021,224:112691

4. Ying Liu# , Dandan Yan# ,Yiqi Wang,Xing Zhang, Na Wang,  Yang Jiao ,Hong Yan*.Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum.Toxicology Letters, 2021,340 : 23–32

5. Yiqi Wang, Ying Liu, Hong Yan*，Effect of Long-term Particulate Matter Exposure on Parkinson’s Risk", Environmental Geochemistry and Health.2020 ，42:2265–2275

6. Ying Liu , Xing Zhang，, Dandan Yan , Yiqi Wang , Na Wanga , Yufan Liu , Aijun Tan,Xiaoyi Chen , Hong Yan*.Chronic acrylamide exposure induced glia cell activation, NLRP3 inflammasome upregulation and cognitive impairment. Toxicology and Applied Pharmacology,2020, 393: 114949

7. Dandan Yan, Xiaoqi Pan,Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Yan*. MAPKs and NF-κB mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5. Journal of Cellular Biochemistry. 2019.3, 120: 3898~3910

8. Dandan Yan, Jianling Yao，Ying Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan*. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin.  Brain, Behavior, and Immunity. 2018, 71: 66-80

9. Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan*. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs.  Toxicology Letters.2018,288：55-64

10. Dandan Yan, Yunjian Zhang, Liegang Liu, Nian Shi, Hong Yan*. Pesticide exposure and risk of Parkinson's disease: Dose-response meta-analysis of observational studies. Regulatory Toxicology and Pharmacology. 2018, 96:57-63

11. Xiaoqi Pan, Dandan Yan, Dun Wang, Xu Wu, Wanyun Zhao, Qing Lu, Hong Yan*. Mitochondrion-mediated apoptosis induced by Acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 Cells. Molecular Neurobiology. 2017; 54(6):4781-4794