職務：副研究員、博士生導師
地址：8858ccl8利网址同濟醫學院8858ccl8利官网1号樓609室
郵箱：xiasheng@hust.edu.cn
研究簡介
盛夏，挪威奧斯陸大學分子生物學博士、博士後；2018年作為引進人才加入8858ccl8利网址8858ccl8利官网環境醫學研究所。從事内質網應激在疾病起源和發展中的作用機制研究，發表SCI論文50餘篇，以第一或通訊作者（含共同）在Advanced Science，Nature Communications，EMBO Molecular Medicine等主流期刊發表論文15篇，累計引用超千次。
研究方向
1. 神經毒理：從内質網應激的角度闡明環境因素損傷認知發育的毒理機制
2. 腫瘤防治：從内質網穩态的角度探索腫瘤預警新策略與靶向幹預新機制
學術兼職
1. 中國環境誘變劑學會緻突變專業委員會青年委員
2. Frontiers in Endocrinology特邀編輯
3. Advanced Science、EMBO Mol Med等期刊審稿人
科研項目
1. 中央軍委後勤保障部研究項目，骨幹
2. 湖北省自然科學基金面上項目，主持
3. 國家自然科學基金青年基金，主持
4. 8858ccl8利网址自主創新基金，主持
獎勵榮譽
2022 8858ccl8利网址青年五四獎章
2021 湖北省“百人計劃”
2015、2019 奧斯陸大學年度最佳生命科學類論文（2次）
2010 中國-歐盟“世界之窗”獎學金
代表論文（#共同第一作者，*通訊作者）
1. Xiao R#, You L#, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G*, Sheng X*, Sun C*. Inhibiting the IRE1α axis of the unfolded protein response enhances the anti-tumor effect of AZD1775 in TP53 mutant ovarian cancer. Advanced Science. 2022: e2105469.
2. Shi C#, Zhao F#, Zhang T#, Xu D, Hao Z, Cui F, Shi JH, Jin Y, Li N, Yang C, Zhang Y*, Sheng X*. A novel prognostic signature in osteosarcoma characterized from the perspective of unfolded protein response. Clinical and Translational Medicine, 2022; 12: e750.
3. Wang G#, Zhang M#, Meng P#, Long C#, Luo X#, Yang X, Wang Y, Zhang Z, Mwangi J, Kamau PM, Dai Z, Ke Z, Zhang Y, Chen W, Zhao X, Ge F, Lv Q, Rong M, Li D, Jin Y*, Sheng X*, Lai R*. Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. Acta Pharmaceutica Sinica B. 2022; 12(5): 2268-2279.
4. Cui F#, Pan Q#, Wang S, Zhao F, Wang R, Zhang T, Song Y, He J, Zhang H, Weng Q, Jin Y, Xia W, Li Y, Yang GY, De Vos W, Timmermans JP, Xu S*, Tang Y*, Sheng X*. Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring. Advanced Science. 2021; 8(23): e2102686. (卷首故事)
5. Zhang P#*, Li S#, Zhang T, Cui F, Shi JH, Zhao F*, Sheng X*. Characterization of molecular subtypes in head and neck squamous cell carcinoma with distinct prognosis and treatment responsiveness. Frontiers in Cell and Developmental Biology. 2021; 9: 711348.
6. Zhang T, Li N, Sun C, Jin Y, Sheng X*. MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? EMBO Molecular Medicine. 2020; 12(5): e11845.
7. Zhang W, Liu W, Bao S, Liu H, Zhang Y, Zhang B, Zhou A, Chen J, Hao K, Xia W, Li Y, Sheng X*, Xu S*. Association of adverse birth outcomes with prenatal uranium exposure: A population-based cohort study. Environment International. 2020; 135: 105391. (IF=9.6)
8. Sheng X, Nenseth HZ, Qu S, Kuzu OF, Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, Mills IG, Danielsen H, Theis F, Patterson JB, Jin Y, Saatcioglu F. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications. 2019; 10(1): 323. (Nature Reviews Urology研究亮點，ESI高被引)
9. Wang Y, Wang K, Jin Y, Sheng X*. Endoplasmic reticulum proteostasis control and gastric cancer. Cancer Letters. 2019; 449: 263-271.
10. Sheng X#, Arnoldussen YJ# Storm ML#, Tesikova M, Jin Y, Nenseth HZ, Zhao S, Mills IG, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Hotamisligil GS, Saatcioglu F. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Molecular Medicine. 2015; 7(6): 788-801.
學術會議
1. 大會負責人，2021年内質網蛋白穩态與疾病國際學術會議。2021年10月，湖北武漢。
