教授, 博士生導師

一、主持科研項目（課題）情況（按時間倒序排序）:

1. 國家自然科學基金面上項目，82473626，槲皮素靶向SOD1調控氧化應激驅動的腎小管上皮細胞衰老改善糖尿病腎病的研究，2025/01-2028/12，49萬，在研，主持

2. 2024年國家重點研發計劃，2024YFF1106204，功能蛋對不同營養特需人群的幹預作用及蛋品健康功效數據庫構建（子課題），2024/12-2027/12，70萬，在研，主持。

3. 湖北省自然科學基金創新發展聯合基金重點項目，腸道菌群在酵母β-葡聚糖改善衰老相關認知障礙中的作用及機制研究，2024/03-2027/02，20萬，在研，主持。

4. 武漢市科技局專項，2020020601012246，衰老細胞啟動細胞競争誘導凋亡在糖尿病腎病中的作用及榭皮素幹預，2020/08-2022/12，50萬，結題，主持。

5. 國家自然科學基金面上項目，81872619，Rab7介導的線粒體自噬和外泌體在酒精性肝鐵過載的協同機制及槲皮素幹預研究，2019/01-2022/12，57萬，結題，主持。

6. 2018年國家重點研發計劃，2018YFC1604003，食品安全大數據關鍵技術研究課題“食品安全大數據智能應用技術研究”，2018/12-2021/12，30萬，結題，子課題負責人。

7. 安琪營養基金科研項目資助，20191685，布拉氏酵母對兒童急性腹瀉的随機雙盲安慰劑對照臨床研究，2019/7-2021/7，40萬，在研，主持。

8. 湖北省自然科學基金面上項目，2018CFB480，應用蛋白質組學分析Frataxin缺失對酒精性肝線粒體自噬的作用及其機制，2018/01-2019/12，結題，主持。

9. 國家自然科學基金委員會，青年基金，81402673，FOXO3-Frataxin介導的肝髒線粒體酒精性損傷及槲皮素幹預機制，2015/01-2017/12，結題，主持。

10. 中國博士後科學基金，第56批中國博士後基金面上項目，130324，ALD中Parkin和受體介導的線粒體自噬失衡及槲皮素幹預，2014/01-2015/12，結題,主持。

二、以第一作者或通訊作者身份發表的代表性論著

(1) Li Chen, Bangfu Wu, Li Mo, Huimin Chen, Xingzhu Yin, Ying Zhao, ZhaoYu Cui, Feipeng Cui, Liangkai Chen, Qianchun Deng, Chao Gao, Ping Yao, Yanyan Li, and Yuhan Tang*. High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan. Nature Communications. 2025.

(2) Huimin Chen, Chao Gao, Li Mo, Xingzhu Yin, Li Chen, Bangfu Wu, Ying Zhao, Xueer Cheng, Chanhua Liang, Bichao Xu , Dongyan Li, Yanyan Li, Ping Yao, Yuhan Tang*. Interleukin 33 promotes liver sinusoidal endothelial cell dysfunction and hepatic fibrosis in diabetic mice. Diabetes & Metabolism Journal. 2025.

(3) Li Chen, Chao Gao, Xingzhu Yin, Li Mo, Xueer Cheng, Huimin Chen, Chunjie Jiang, Bangfu Wu, Ying Zhao, Hongxia Li, Yanyan Li, Jiansha Li, Liangkai Chen, Qianchun Deng, Ping Yao, Yuhan Tang*. Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy. MedComm (2020). 2024 Oct 24;5(11):e742.(IF=10.7)

(4) Li Chen, Bangfu Wu, Li Mo, Huimin Chen, Ying Zhao, Tianqi Tan, Liangkai Chen, Yanyan Li, Ping Yao, Yuhan Tang*. Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies. Lancet Healthy Longev. 2023 8:S2666-7568(23)00220-9. (IF=13.4)

(5) Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang*. Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults. BMC Med. 2022, 20(1): 207.( IF=11.81)

(6) Zhuangyu Zhang, Fangqu Liu, Xingzhu Yin, Bangfu Wu, Hongxia Li, Fei Peng, Maowei Cheng, Jingjing Li, Jingjing Xiang, Ping Yao, Shuang Liu, Yuhan Tang*. Chinese Healthy Eating Index (CHEI) and risk of diabetes in Chinese adults: a prospective cohort study. Eur J Nutr. 2024, 63(3): 939-949. (IF=5.0)

(7)  Jingjing Liu, Huimin Chen, Hongkun Lin, Shufen Peng, Li Chen, Xueer Cheng, Ping Yao,Yuhan Tang* Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction. J Nutr Biochem. 2023, 114: 109258. (IF=5.6)

(8) Xueer Cheng, Yanyan Li, Li Chen, Chunjie Jiang, Shufen Peng, Ping Yao, Yuhan Tang*. Excess iron accumulation mediated senescence in diabetic kidney injury. J Biochem Mol Toxicol. 2024, 38(4): e23683. (IF=3.6)

(9) Huimin Chen, Jingjing Liu, Shufen Peng, Guang Yang, Xueer Cheng, Li Chen, Han Zhang, Ying Zhao, Ping Yao, Yuhan Tang. Autophagy and exosomes coordinately mediate quercetin’s protective effects on alcoholic liver disease. J Nutr Biochem. J Nutr Biochem. 2023, doi: 10.1016/j.jnutbio.2023.109332. (IF=5.6)

(10) Huimin Chen, Yuhan Tang. Iron-loaded Extracellular Vesicles: Angel or Demon? Free Radical Res. 2023, doi: 10.1080/10715762.2023.2191813. (IF=3.3, )

(11) Li Chen, Xingzhu Yin, Ying Zhao, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang*. Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study. J Epidemiol Community Health. 2022, doi: 10.1136/jech-2022-219142. (IF=6.3)

(12) Chen L, Sun Q, Peng S, Tan T, Mei G, Chen H, Zhao Y, Yao P, Tang Y*. Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999-2018. Chemosphere. 2022, 289:133147. (IF=8.9)

(13) Shufen Peng, Huimin Chen, Li Chen, Guang Yang, Jingjing Liu, Xueer Cheng, Yuhan Tang*. Beyond Isocitrate Dehydrogenase Mutations: Emerging Mechanisms for the Accumulation of the Oncometabolite 2-Hydroxyglutarate. Chem Res Toxicol. 2022,35(2):115-124. (IF=4.1)

(14) Lin Xiao, Gang Luo, Hongxia Li, Ping Yao*, Yuhan Tang*. Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism. BBA- Mol Cell Biol L. 2021,1866(10):159004. (IF=4.8)

(15) Li Chen, Jing Liu, Guibin Mei, Huimin Chen, S Peng, Ying Zhao, Ping Yao, Yuhan Tang*. Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis. Food Chem Toxicol. 2021, 154:112314. (IF=5.5)

(16) Hongxia Li, Lin Xiao, Hui He, Hongmei Zeng, Jingjing Liu, Chunjie Jiang, Guibin Mei, Jiasheng Yu, Hao Chen, Ping Yao*, Yuhan Tang*. Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Galectin-3-NLRP3 Signaling Pathway. Mol Nutr & Food Res. 2021, 65(15):e2000746. (IF=6.5)

(17) Li Chen, Guibin Mei, Chunjie Jiang, Xueer Cheng, Dan Li, Ying Zhao, Hunmin Chen, C Wan, Ping Yao, Chao Gao*, Yuhan Tang*. Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy. Cell Prolif. 2021, 54(6):e13052. (IF=8.7)

(18) Jingjing Liu, Hui He, Jing Wang, Xiaoping Guo, Hongkun Lin, Huimin Chen, Chunjie Jiang, Li Chen, Ping Yao*, Yuhan Tang*, Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis, Toxicology, 2020, 445: 152584. (IF=4.2)

(19) Chao Gao, Yang Liu, Chunjie Jiang, Liang Liu, Juan Li, Dan Li, Xiaoping Guo, Zhu Wang, Yuexin Yang, Liegang Liu, Ping Yao, Yuhan Tang*. Intensive Running Enhances NF-κB Activity in the Mice Liver and the Intervention Effects of Quercetin, Nutrients, 2020, 12:2770. (IF=5.7)

(20) Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, YuhanTang*. Ping Yao*. Quercetin ameliorates HFD-induced NAFLD bypromotinghepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway, Food Chem Toxicol, 2018, 114: 52-60.

(21) Lin Xiao, Gang Luo, Yuhan Tang*, Ping Yao*. Quercetin and ironmetabolism: What we know and what we need to know, Food Chem Toxicol, 2018, 114: 190-203.

(22) Peiyi Liu, Hongkun Lin, Yanyan Xu, Feng Zhou, Jing Wang, Jingjing Liu,Xinhong Zhu, Xiaoping Guo, YuhanTang*. Ping Yao*. Frataxin-Mediated PINK1-Parkin-Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin, Mol Nutr &Food Res, 2018,62(16):e1800164.

(23)Yanyan Li, Chen M, YanyanXu, Xiao Yu, Ting Xiong, Min Du, Jian Sun, LiegangLiu, YuhanTang*, Ping Yao*. Iron-mediated Lysosomal Membrane Permeabilization in Ethanol Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin, Oxid Med Cell Longev, 2016, 2016: 4147610.

(24) Lin Xiao, Liang Liu, Xiaoping Guo, Shanshan Zhang, Jing Wang, Feng Zhou, LiegangLiu, YuhanTang*, Yao P*. Quercetin attenuates high fat diet-induced atherosclerosis inapolipoprotein Eknockout mice: A critical role of NADPH oxidase, Food Chem Toxicol, 2017, 105: 22-23.

(25) YuhanTang#, YanyanLi, Haiyan Yu, Chao Gao, Liang Liu, Shaodan Chen, Mingyou Xing, Liegang Liu, Ping Yao*. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway, J Nutr Biochem,2014, 25(6):675-82.

(26) YuhanTang, Juan Li, Chao Gao, YanyanXu, YanyanLi, Xiao Yu, Jing Wang, LiegangLiu, Ping Yao*. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress andInflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinaseand Nuclear Factor-Kappa B, Oxid Med Cell Longev, 2016,2016:8696587.

(27) Xiao Yu, YanyanXu, Shanshan Zhang, Jian Sun, PeiyiLiu, Lin Xiao, YuhanTang*, LiegangLiu, Ping Yao*. Quercetin Attenuates Chronic  Ethanol-Induced Hepatic Mitochondrial Damagethrough Enhanced Mitophagy,Nutrients, 2016, 8(1): 27.

(28) YuhanTang,YanyanLi, Haiyan Yu, Chao Gao, Liang Liu, MingyouXing, LiegangLiu, Ping Yao*. Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release, Food Chem Toxicol, 2014, 67: 131-138.

(29) YuhanTang#, HongtaoTian#, YanruShi, Chao Gao, MingyouXing,Wei Yang, Wei Bao, Di Wang, LiegangLiu, Ping Yao*, Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity viadepleting heme pool and releasing CO,Phytomedicine, 2013, 20(8-9):699-704.

(30) YuhanTang#, Chao Gao#, MingyouXing, YanyanLi, LipingZhu, Di Wang, XuefengYang, LiegangLiu, Ping Yao*, Quercetin prevents ethanol-induced dyslipidemia and mitochondrialoxidative damage, Food Chem Toxicol, 2012, 50(5):1194-1200.

(31) YuhanTang, Chao Gao, YanruShi, LipingZhu, Hu XM, Di Wang, Liu Yang, XuefengYang, LiegangLiu, Ping Yao*, Quercetin attenuates ethanol-derived microsomal oxidative stress: Implication of haem oxygenase-1 induction,Food Chem, 2012,132(4):1769-1774.

(32) YuhanTang#, Jian Xu, Wei Qu, Xiaolin Peng, Peng Xin, Xuefeng Yang, Chenjiang Ying, XiufaSun, Liping Hao*, Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms, J Nutr Biochem, 2012, 23(11): 1410-1416.

三、參編教材或專著

1. 社區營養與健康管理，人民衛生出版社、124-136頁，2020年12月，編委。

2. 真菌毒素污染與健康，湖北科技出版社、1-24，2021年12月，副主編。

3. 臨床營養學（“十一五”國家級規劃教材第四版），科學技術出版社，2025年1月，編委兼秘書

四、獲獎或社會服務

1. 中國營養學會社區營養與健康管理分會常務委員

2. 中國學生營養與健康促進會大學生健康分會副秘書長

3. 中華預防醫學營養與健康分會委員

4. 中國科學技術協會科普專家

5. 湖北省國民營養健康專家委員會委員

6. 武漢營養學會秘書長

7. 唐玉涵(3/5); 植物黃銅誘導HO-1拮抗酒精性肝病的機制, 湖北省人民政府, 自然科學, 省部二等獎, 2014(劉烈剛;姚平;唐玉涵; 郝麗萍; 楊雪鋒)。

8. 《中小學生食品安全知識讀本叢書》獲得中國營養科學技術進步獎二等獎。

9. 教育部首批一流本科課程《食源性疾病現場調查與處理》