王愛國，1982.09―1987.07 湖南醫科大學衛生系，本科學曆/學士學位。1989.09―1992.07 8858ccl8利网址同濟醫學院8858ccl8利官网環境衛生學教研室碩士研究生，獲醫學碩士學位，導師陳學敏教授。1997.08―1999.10 德國Ulm大學博士研究生，獲醫學博士學位，導師Andreas Nüssler。自1987年7月參加工作以來一直從事環境衛生學和環境毒理學的教學和科研工作。主要研究領域為外源性化合物的毒性作用及其分子機制研究，研究成果榮獲湖北省自然科學獎一等獎和教育部自然科學獎二等獎。主要社會兼職有中國毒理學會第二屆神經毒理專業委員會常務委員及中華醫學會地方病學分會委員等。
主要負責的科研項目
1. 線粒體動力學改變在氟神經毒性中的作用及白藜蘆醇幹預效果研究（No. 81430076），2015.1-2019.12，國家自然科學基金重點項目，320.0萬元，課題負責人
2. 自噬與凋亡在PBDE-47神經毒性中的作用研究（No. 81273021），2013.1-2016.12，國家自然科學基金面上項目，70.0萬元，課題負責人
3. 内質網應激及UPR信号通路在PBDE-47神經毒性中的作用（No. 81072266），2011.1-2013.12，國家自然科學基金面上項目，34.0萬元，課題負責人
4. 數字PET在環境污染物緻神經毒性研究中的應用（No. 0118513100），8858ccl8利网址2015年創新交叉重點團隊自主創新基金，50.0萬，課題負責人
代表性論著
1. Shun Zhang#, QiangNiu, Hui Gao, Rulin Ma, Rongrong Lei, Cheng Zhang, Tao Xia, Pei Li, Chunyan Xu, Chao Wang, Jingwen Chen, Lixing Dong, Qian Zhao, Aiguo Wang*. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016, 212:97-104.
2. Shun Zhang#, Yihu Chen, Xue Wu, Hui Gao, Rulin Ma, Chunyang Jiang, Gang kuang, Guodong Zhao, Tao Xia, Xiaofei Zhang, Rongrong Lei, Cheng Zhang, Pei Li, Chunyan Xu, Aiguo Wang*. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis.MolNeurobiol.2015 (Epub ahead of print).
3. Shun Zhang#, Xiaofei Zhang#, Hongliang Liu, Weidong , Zhizhong Guan, Qiang Zeng, Chunyang Jiang, Hui Gao, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Yushan Cui, Linyu Yu, and Aiguo Wang*. Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China.Toxicol Sci. 2015, 144(2):238-45.
4. Chunyang Jiang#, Shun Zhang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Aiguo Wang*. Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain.Neuromol Med. 2014, 16(1): 94-105.
5. Zhixia Xu#, Bayi Xu, Tao Xia, Weihong He, Ping Gao, LijuanGuo, Zhenglun Wang, QiangNiu, Aiguo Wang*.Relationship between intracellular Ca2+and ROS during fluoride-induced injury in SH-SY5Y cells.Environ Toxicol. 2013, 28(6):307-312.
6. Shun Zhang#, Chunyang Jiang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Hui Gao, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Zhenglun Wang, Aiguo Wang*. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. ToxicolApplPharmacol. 2013, 271(2):206-215.
7. Shun Zhang#, Gang Kuang#, Guodong Zhao, Xue Wu, Cheng Zhang, Rongrong Lei, Tao Xia, Jianbin Chen, Zhenglun Wang,, Rulin Ma,, Bei Li,, Lu Yang, Aiguo Wang*. Involvement of the mitochondrial p53 pathway in PBDE-47-induced SH-SY5Y cells apoptosis and its underlying activation mechanism. Food ChemToxicol. 2013.62:699-706.
8. Chunyang Jiang#, Shun Zhang#, HongLiang Liu, Qiang Zeng, Tao Xia, Yihu Chen, Gang Kuang, Guodong Zhao, Xue Wu, Xiaofei Zhang, Aiguo Wang*. The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro.Toxicol Lett. 2012, 211(3):325-33.
9. QiangNiu#, HongLiang Liu, ZhiZhong Guan, Qiang Zeng, ShuXiaGuo, Ping He, LiJuanGuo, Ping Gao, BaYi Xu, ZhiXia Xu, Tao Xia, Aiguo Wang*. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02Cells.BiolTrace Elem Res. 2012, 149(1):102-9.
10. Bayi Xu#, Zhixia Xu, Tao Xia, Ping He, Ping Gao, Weihong He, Ming Zhang, LijuanGuo, QiangNiu, Aiguo Wang*. Effects of the Fas/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells.Environ Toxicol. 2011, 26(1):86-92.
11. Ping He#, Aiguo Wang*, QiangNiu, LijuanGuo, Tao Xia, Xuemin Chen.Toxic effect of PBDE-47 on thyroid development, learning, and memory, and the interaction between PBDE-47 and PCB153 that enhances toxicity in rats.Toxicol Ind Health. 2011, 27(3):279-88.
